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Question

Two switch: ADRF5049 and HMC7992. How should unused ports be handled? 

Floating (not connected) or with an external 50 ohm resistor?

Answer

he ADRF5049 and HMC7992 are nonreflective RF switches with internal 50 Ω terminations on all unselected ports. External terminations are not required for normal operation.
For permanently unused ports, provide DNP footprints for optional 50 Ω loads to support characterization, debugging, and protection against unintended port selection.